The mechanism of action is the way in which drugs for the treatment of obesity (FDA approved) are qualified.
So are the anorexigens (decreasing appetite), termogenics (increasing energy), and inhibitors (reducing fats ingested, at a gastrointestinal level)
Anorexigens:
- Sibutramine (Reductil, Meridia, Florinef, etc.) belongs to this group. Its central mechanism of action acts by inhibiting the receiving serotonin and norepinephrine, and by increasing the sense of satiety (being full). It also increases the thermogenic activity (energy spent) through a sympathomimetic effect.
Absorption Inhibitors:
- Orlistat (Xenical, Alli, etc.) belongs to this group. It reduces the absorption of fat up to a 30% by intestinal inhibition of lipase. Orlistat is not absorbed into the bloodstream, making it one of the safest (if not the most) drugs, with fewer side effects, and without any major problems for interaction with other medicines.
There also are dietary fiber (glucomanano, methylcellulose, etc).
Used to produce a feeling of satiety, thus decreasing the appetite.
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Thursday, November 22nd, 2007 at
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Treatment of Obesity .
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